Endocrine Abstracts

Introduction: Stress is a known risk factor for the development of Graves’ disease. We have previously described the role of bereavement as an inducing factor for Graves’ disease. Bereavement as an inducing factor for Graves’ disease was shown to affect primarily female patients after the loss of a loved one. However, it appears that other stressful life events may also cause Graves’ disease.Aim: The aim of the study was to describe t...

Background and aims: Gestational diabetes (GD) is closely related to unbalanced zinc (Zn) and cooper (Cu) serum levels. The aim of this study was to investigate serum zinc and cooper levels in relation to the metabolic profile, and the impact on fetal development in a cohort of gestational diabetes GD(N) neonates and their mothers GD(M) compared to normal pregnancies.Material and Methods: Prospective controlled study in a tertiary Academic medical center...

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

Background: Intestinal metaplasia (IM) of the gastric mucosa is a relatively frequent precancerous lesion. The aim of the study was to assess the prevalence and the kind of IM and also to find parameters that could predict the presence of IM in gastric neuroendocrine neoplasms type 1 (GNEN1).Methods: Fifty-nine (45 females) patients with GNEN1 were retrospectively studied. All patients included in the study had positive parietal-cell antibodies. All pati...

Introduction: IgG4 Related Hypophysitis (IgG4-RH) is a newly recognized form of hypophysitis. It usually appears as part of IgG4-Related Disease (IgG4-RD), an immune mediated disease, with manifestations in many organs. Isolated hypophysitis without other IgG4-RD manifestations is rare.Presentation: A 64 years old female referred to our department for further investigation of a 9 month history of fatigue, muscle weakness, recurrent episodes of right temp...

Aim: Thyroid cancer comprises the most common endocrine malignancy and a variety of studies have investigated the role of thyroid autoimmunity as an independent risk factor for the manifestation of differentiated thyroid cancer in otherwise benign thyroid disorders. Objective of the current retrospective study is the assessment of any possible correlation between thyroid autoimmunity, in terms of elevated thyroid autoantibodies, and incidental thyroid microcarcinoma (ITC) in n...

Introduction: Osteoporosis is a chronic and dangerous disease, as it may be silent and may express itself with a sudden catastrophic event, such as a fracture. Treatment of osteoporosis demands the use of potent pharmaceutical agents with long lasting effects. In particular, bisphosphonates, such as ibandronate, may be used. It has become evident that chronic treatment with anti-osteoporotic agents may reverse the course of the disease, patients having normal bone mineral dens...

Introduction: Barrett’s esophagus is metaplasia in the cells of the lower end of the esophagus. It is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells. The disease is often related to gastroesophageal reflux and patients have pain necessitating chronic usage of proton pump inhibitors. Proton pump inhibitors have been associated with the development of low bone mineral dens...

Objective: To report a case of hypogonadism reversal and spontaneous puberty in a craniopharyngioma patient who suffered from hypopituitarism as a result of complete surgical resection.Methods: A 13-year-old boy with hypopituitarism was evaluated for right testicular sensitivity.At the age of 6 the child presented with growth arrest and a craniopharyngioma causing pituitary insufficiency was diagnosed. Treatment with hydrocortisnon...

Introduction: Hypoglycemia consists a significant problem in insulin treated type 2 diabetic patients. The present study compared the incidence of hypoglycemic episodes in type 2 diabetics between continuous glucose monitoring/CGM vs self monitoring of blood glucose/SMBG.Methods: Seventeen patients with type 2 diabetes underwent a 24 h CGM for a period of 3–5 consecutive days. At the same period they recorded their glucose values using SMBG from fou...